The Chiefs are the current leaders of the AFC West and are on a six-game winning streak since October 24, when they were beaten 27-3 by the Tennessee Titans.
For their part, the Chargers have won the last two games and three of the last four and could even their record with their opponents on Thursday.
Led by quarterback Justin Herbert, Los Angeles has scored at least 35 points in three of its last four games. Overall, the Chargers have scored at least 35 points in four games this season; just two teams this year have more 35-point games.
The all-time series is 64-58-1 in favor of Kansas City.
Kickoff from SoFi Stadium in Los Angeles, California is set for 6:20 p.m PT (local time).
How to watch
Network: FOX/NFL Network
FOX: Los Angeles and Orange County: Channel 11 (KTTV)
Play-by-play: Joe Buck
Analyst: Troy Aikman
Sideline: Erin Andrews & Kristina Pink
Odds and betting lines for Chiefs vs. Chargers:
Chiefs vs. Chargers spread: Kansas City -3
Chiefs vs. Chargers over-under: 52 points
Chiefs vs. Chargers money line: Kansas City -160, Los Angeles +140
KC: Chiefs are 4-0 against the spread in their last four games overall
LAC: Chargers are 5-1 ATS in their last six Thursday games
Kansas City Chiefs Participation/Injury Report
CB L’Jarius Sneed NIR (personal) – DNP
LB Nick Bolton Wrist – Full
DT Derrick Nnadi Elbow – Full
CB Rashad Fenton Knee – Full
OL Lucas Niang Ribs – Full
LB Willie Gay COVID – Full
G Andrew Wylie Knee – Full
Los Angeles Chargers Participation/Injury Report
TE Jared Cook Quadricep – Limited
RB Austin Ekeler Ankle – Limited
S Alohi Gilman Quadricep – Limited
S Derwin James Jr. Hamstring – Limited
DL Justin Jones Ankle/Knee – Limited
DL Linval Joseph Shoulder – Limited
DB Trey Marshall Ankle/Head – Limited
TE Donald Parham Jr. Knee – Limited
CB Asante Samuel Jr. Concussion – Limited
WR Mike Williams Heel – Limited